Evaluation of the Antitoxic Effect of Phthalides from Apium graveolens in Acrylamide Intoxication I. Evolution of the Hepatic Cytolysis and Proteosynthetic Parameters in Acrylamide Intoxication on the Background of Phthalide Protection

  • Cornelia PRISACARU University of Agricol Sciences and Veterinary Medicine Iasi, Faculty of Veterinary Medicine; Aleea Mihail Sadoveanu nr.8, Iasi
  • Anca Irina BURLACU University of Agricultural Sciences and Veterinary Medicine Iasi, Faculty of Veterinary Medicine, 8 Mihail Sadoveanu St.

Abstract

Acrylamide is a toxic compound formed during thermical processing of foods that contain amino acids, mainly asparagine, and reducing sugars. The toxicodynamics of acrylamide, exerted mainly by its major metabolite glycidamide, is expressed by mutagenic, carcinogenic and imunosupressive effects. Due to its toxicity and its high prevalence in aliments, the present paper approaches a possible way of reducing the toxic effects of acrylamide by using phytotherapeutical means. In this direction, the antitoxic potential of some phytopreparates obtained from Apium graveolens (Apii aetheroleum, extractive solutions from A. radix, A. folium and A. semen) were monitorized on the background of acrylamide intoxication. The antitoxic potential of phthalides has been evaluated by determining biochemical parameters: hepatic cytolysis parameters (aspartate aminotransferase, alanil aminotransferase, lactate dehydrogenase) and protesosynthesis parameters (colinesterase, total poteins, albumins). The biochemical investigation confirmed the antitoxic potential fo phthalides from celery, the highest protection being obtained for the phytopreparate from Apii semen.

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Published
2009-11-02
How to Cite
PRISACARU, C., & BURLACU, A. I. (2009). Evaluation of the Antitoxic Effect of Phthalides from Apium graveolens in Acrylamide Intoxication I. Evolution of the Hepatic Cytolysis and Proteosynthetic Parameters in Acrylamide Intoxication on the Background of Phthalide Protection. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 37(2), 129-133. https://doi.org/10.15835/nbha3723200
Section
Research Articles