Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract


  • Sabina-Emanuela ERHAN Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084; Babeș-Bolyai University, Doctoral School of Integrative Biology, Republicii Street 44, Cluj-Napoca 400015; National Institute for Research and Development of Isotopic and Molecular Technologies, Donath Street 67-103, Cluj-Napoca 400293 (RO)
  • Alina E. PÂRVU Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pathophysiology, Victor Babes Street 4, Cluj-Napoca 400012 (RO)
  • Alexandra CIORÎȚĂ Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084 (RO)
  • Ayu A. PUTRI Universitas Airlangga, Faculty of Medicine, Jl. Mayjen Prof. Dr. Moestopo Street 47, Surabaya 60131 (ID)
  • Alexis J. VILLAGRANA MOLINA Autonomous University of Zacatecas, Academic Unit of Human Medicine and Health Sciences, Carretera a Guadalajara KM. 6, Zacatecas, Ejido la Escondida S/N 98160 (MX)
  • Marcel PÂRVU Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084; Babeș-Bolyai University, Doctoral School of Integrative Biology, Republicii Street 44, Cluj-Napoca 400015 (RO)
  • Augustin C. MOȚ Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany Janos Street 11, Cluj-Napoca 400028 (RO)



alkaloids, Amur cork tree, anti-inflammatory, antioxidant, polyphenols


In many diseases inflammation and oxidative stress coexist and are therapeutic targets. Phellodendron amurense Rupr. has anti-inflammatory and antioxidant effects, but the mechanisms are not completely elucidated. Therefore, first P. amurense stem bark extract was analysed regarding chemical compounds such as total polyphenol content (TPC), polyphenols (gallic acid, 4-hydroxybenzoic acid, caffeic acid and ferulic acid) and alkaloids (berbamine, jatrorrhizine, palmatine, and berberine). Quantitative determination of alkaloids revealed that berberine had the highest concentration of 2.44±0.22 mg/g. In vitro antioxidant activity was significant. Then, thein vivo anti-inflammatory and antioxidative effects of P. amurense extract were studied before and after acute experimental rat inflammation induction in order to find some mechanisms of these effects. The P. amurense stem bark extract had a good anti-inflammatory activity by reducing nitric oxide, 3-nitrotyrosine and NF-kB, and an antioxidant activity by lowering oxidants and increasing antioxidants. This study provides scientific knowledge and could contribute to the development of novel drugs based on P. amurense stem bark extract for the treatment of inflammatory diseases and prevention of oxidative stress.


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How to Cite

ERHAN, S.-E., PÂRVU, A. E., CIORÎȚĂ, A., PUTRI, A. A., VILLAGRANA MOLINA, A. J., PÂRVU, M., & MOȚ, A. C. (2023). Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 51(3), 13306.



Research Articles
DOI: 10.15835/nbha51313306

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