Hexane extract of Telosma cordata enhances neurite outgrowth via the epigenetically regulated genes expression in neuronal cells


  • Nguyet Thi DOAN Vietnam Academy of Science and Technology, Center For High Technology Development, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000 (VN)
  • Hung Minh NGUYEN Duy Tan University, College of Medicine and Pharmacy, Center for Pharmaceutical Biotechnology, Da Nang, 55000 (VN)
  • Tuyet Loan Thi BUI Vietnam Academy of Science and Technology, Center For High Technology Development, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000 (VN)
  • Huyen Trang Thi NGUYEN University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000 (VN)
  • Duong Hoang NGUYEN Vietnam Academy of Science and Technology, Center For High Technology Development, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000 (VN)
  • Tru VAN NGUYEN Vietnam Academy of Science and Technology, Instute of Biotechnology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000 (VN) https://orcid.org/0000-0001-6669-9094




AChE inhibitory, BDNF, neurite outgrowth, neurological diseases, NGF genes, Telosma cordata


Telosma cordata has long been consumed as foods and herbal medicine. The aim of this research is to investigate the potential biological activities of Telosma cordata flower (TCF) extracts and their molecular mechanisms in the treatment of neurological diseases, especially dementia. In general, the plant samples were successfully identified through DNA barcoding regions, utilizing matK, trnH-psbA, and rbcL markers. The ethanol extract and its fraction exhibited significantly high acetylcholinesterase inhibitory activity. Moreover, hexane extract of T. cordata displayed the most potent neurotrophic activity in a preliminary cell-based screening based on C6 cells neurite outgrowth. Additionally, hexane extract of T. cordata demonstrated the highest antioxidant activity. Finally, the hexane extract of T. cordata upregulated the expression of BDNF, NGF and acetyl H3 in C6 cells, affecting both mRNA and protein levels. These findings indicate that Telosma cordata could be a strong candidate for developing pharmacological drugs to treat dementia and neurodegenerative diseases.

Author Biographies

Hung Minh NGUYEN, Duy Tan University, College of Medicine and Pharmacy, Center for Pharmaceutical Biotechnology, Da Nang, 55000



Tuyet Loan Thi BUI, Vietnam Academy of Science and Technology, Center For High Technology Development, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000



Huyen Trang Thi NGUYEN, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 100000




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How to Cite

Thi DOAN, N., Minh NGUYEN, H., Thi BUI, T. L., Thi NGUYEN, H. T., NGUYEN, D. H., & VAN NGUYEN, T. (2023). Hexane extract of Telosma cordata enhances neurite outgrowth via the epigenetically regulated genes expression in neuronal cells. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 51(4), 13204. https://doi.org/10.15835/nbha51413204



Research Articles
DOI: 10.15835/nbha51413204

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