Bioactive principles, antibacterial and anticancer properties of Artemisia arborescens L.

Shahnaz SULTANA; Hafiz A. MAKEEN; Hassan A. ALHAZMI; Syam MOHAN; Mohammed AL BRATTY; Asim NAJMI; Husham E. HOMEIDA; Gulrana KHUWAJA; Shehla N.M.N. ULLAH; Ameeduzzafar ZAFAR; Sivakumar S. MONI

doi:10.15835/nbha51113008

Authors

Shahnaz SULTANA Jazan University, College of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan, 45142 (SA)
Hafiz A. MAKEEN Jazan University, College of pharmacy, Department of Clinical Pharmacy, Jazan, 45142 (SA)
Hassan A. ALHAZMI Jazan University, College of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan, 45142; Jazan University, Substance Abuse and Toxicology Research Center, Jazan, 45142 (SA)
Syam MOHAN Jazan University, Substance Abuse and Toxicology Research Center, Jazan, 45142; University of Petroleum and Energy Studies, School of Health Sciences, Dehradun, Uttarakhand; Saveetha University, Center for Transdisciplinary Research, Saveetha Dental College, Department of Pharmacology, Saveetha Institute of Medical and Technical science, Chennai (SA)
Mohammed AL BRATTY Jazan University, College of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan, 45142 (SA)
Asim NAJMI Jazan University, College of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan, 45142 (SA)
Husham E. HOMEIDA Jazan University, College of Dentistry, Department of Maxillofacial Surgery and Diagnostic Sciences, Jazan, 45142 (SA)
Gulrana KHUWAJA Jazan University, College of Pharmacy, Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan, 45142 (SA)
Shehla N.M.N. ULLAH King Khalid University, College of Pharmacy, Department of Pharmacognosy, Abha (SA)
Ameeduzzafar ZAFAR Jouf University, College of Pharmacy, Department of Pharmaceutics, Sakaka 72341, Al-Jouf (SA)
Sivakumar S. MONI Jazan University, College of Pharmacy, Department of Pharmaceutics, Jazan 45142 (SA)

DOI:

https://doi.org/10.15835/nbha51113008

Keywords:

antimicrobial, Artemisia arborescens, cytotoxic activity, phytochemical screening

Abstract

Artemisia arborescens is a medicinal and aromatic plant used in traditionally by the people of Saudi Arabia. This research attempts to evaluate the bioactive constituents of the plant using organic solvents, as well as the antibacterial and anticancer properties of plant extracts. The Phytochemical analysis of methanol extract revealed eleven bioactive constituents, identified by comparing their retention periods and GC-MS profiles to account for 52.45 percent of the studied extract. In the meantime, the extract of pet ether had demonstrated the presence of sixteen significant constituents, six of which were distinct sesquiterpene derivatives. In lipophilic plant extract, three higher alkanes made up 12.49% of the total. These higher alkanes were tetratriacontane (6.55%), hentriacontane (4.17%), and octacosane (1.77%). Studies on antimicrobial activity have revealed that both methanolic and petroleum ether extracts had a broad spectrum of activity against specific human pathogens. Both extracts, however, failed to exhibit any anti-Candida albicans activity. Methanolic extract not shown inhibition in the cell growth of MCF-7 cell, but petroleum ether extract had shown significant anti-cancer activity against MCF-7 cell with an IC₅₀of 13.49 µg/mL. the results obtained show that A. arborescens have a lot of potential for further research into variety of biological functions, against cancer and microbes.

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