Microscopical characteristics, phytochemical investigation and biological activities of different Lysimachia species growing in Vietnam


  • Quang Hung NGUYEN Vietnam Academy of Science and Technology (VAST), Institute of Ecology and Biological Resources, Hoang Quoc Viet 18, Ha Noi; Graduate University of Science and Technology, VAST, Hoang Quoc Viet 18, Ha Noi (VN)
  • Thanh Tung NGUYEN Hanoi University of Pharmacy, Department of Pharmacognosy, Le Thanh Tong 15, Ha Noi (VN)
  • Viet Than NGUYEN Hanoi University of Pharmacy, Department of Pharmacognosy, Le Thanh Tong 15, Ha Noi (VN)
  • Minh Ha LE Vietnam Academy of Science and Technology (VAST), Institute of Natural Products Chemistry, Hoang Quoc Viet 18, Ha Noi (VN)
  • Ain RAAL University of Tartu, Institute of Pharmacy, Faculty of Medicine, Nooruse 1, Tartu 50411 (EE)




biological activity;, characteristics of stems and leaves, Lysimachia, metabolites, powder characteristics


Several species of the genus Lysimachia L. (Primulaceae) are well known in folk medicine, but very few studies have been conducted on them. The aim of our study was to investigate the microscopical characteristics and chemical composition of Lysimachia insignis Hemsl., L. decurrens G. Forst., and L. congestiflora Hemsl. as well as to evaluate some biological activities of their methanol extracts. The transverse sections of stem and powder characteristics of the three Lysimachia species shared some similarities. Also, some differences were indicated. The chemical investigation of three aforesaid species including the preliminary phytochemical screening, the quantification of the total polyphenol content and total flavonoid content, as well as the determination of metabolites. The phytochemical screening showed the presence of flavonoids, saponins, tannins and sterols in all the three species. On the other hand, coumarins were detected in L. insignis while anthranoids were present in L. decurrens and L. congestiflora. The total polyphenol content and the total flavonoid content of the aforesaid species were determined by the spectrometric method. The metabolite profiling approach of three species was performed by LC-Q-ToF-HRMS and HPTLC. The methanol extract of L. insignis showed a weak inhibitory effect on NO production (I% = 57.4 at the concentration of 100 µg/ml) while the extract of L. decurrens exhibited moderate anti-oxidant activity in vitro (SC% = 62.5 at the concentration of 100 µg/mL).


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How to Cite

NGUYEN, Q. H., NGUYEN, T. T., NGUYEN, V. T., LE, M. H., & RAAL, A. (2022). Microscopical characteristics, phytochemical investigation and biological activities of different Lysimachia species growing in Vietnam. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 50(2), 12692. https://doi.org/10.15835/nbha50212692



Research Articles
DOI: 10.15835/nbha50212692