Antioxidant Activity, Total Phenolics and Taxol Contents Response of Hazel (Corylus avellana L.) Cells to Benzoic Acid and Cinnamic Acid

Ebrahim BEMANI, Faezeh GHANATI, Laleh YOUSEFZADEH BOROUJENI, Faezeh KHATAMI

Abstract


Hazel (Corylus avellana L.) plant has been recently introduced as a plant with the ability to produce Taxol. In the present research effects of different concentrations of benzoic acid and cinnamic acid on the phenolic compounds, Taxol content, and antioxidant activity of extracts of suspension-cultured hazel cells were investigated. The cells were treated with different concentrations of benzoic acid (0, 0.5, and 1 mM) and cinnamic acid (0, 0.15, 0.3 and 0.6 mM) on day 7 of subculture and were harvested on day 14. Benzoic acid in higher concentrations increased Taxol (4 fold of the control) and antioxidant activity of the cell extract. Cinnamic acid supply did not bring remarkable increase in Taxol content but increased phenolic contents and antioxidant activity of hazel cells extract. Interestingly, the extract of hazel cells showed more cytotoxicity for human cancer cells than pure Taxol. Further investigations may suggest the extract of cinnamic- and benzoic acid- fed hazel cells for treatment of cancer cells.

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DOI: http://dx.doi.org/10.15835/nbha4017404

June 1, 2018: Notulae Botanicae Horti Agrobotanici Cluj-Napoca in Scopus – Elsevier CiteScore 2017=0.78, Horticulture; Agronomy and Crop Science; Plant Science


 
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